![]() The majority of them demonstrated that the frequency of RARβ promoter methylation was significantly correlated with the severity of cervical epithelium abnormalities. To investigate whether RARβ methylation is a potential biomarker that predicts the progression of invasive cancer, we reviewed 14 previously published articles related to RARβ methylation. Methylation of CpG islands in the promoter region of the RARβ gene has been found to be associated with the development of cervical cancer. The retinoic acid receptor beta ( RARβ) gene, a potential tumor suppressor gene, is usually expressed in normal epithelial tissue. Recent research suggested that methylation has been detected already at precancerous stages, which methylation markers may have significant value in cervical cancer screening. Likewise, epigenetic aberrations have ability to regulate cancer pathogenesis and progression. ![]() Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma. Cervical cancer is one of the leading causes of death in women worldwide, particularly in developing countries. ![]()
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